Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse -cardiac myosin in the laser trap assay
نویسندگان
چکیده
Edward P. Debold, J. P. Schmitt, J. B. Patlak, S. E. Beck, J. R. Moore, J. G. Seidman, C. Seidman, and D. M. Warshaw Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont; Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany; Department of Physiology and Biophysics, Boston University School of Medicine, Boston; Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston; and Cardiovascular Division and Howard Hughes Medical Institute, Brigham and Women’s Hospital, Boston, Massachusetts
منابع مشابه
Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay.
Point mutations in cardiac myosin, the heart's molecular motor, produce distinct clinical phenotypes: hypertrophic (HCM) and dilated (DCM) cardiomyopathy. Do mutations alter myosin's molecular mechanics in a manner that is predictive of the clinical outcome? We have directly characterized the maximal force-generating capacity (F(max)) of two HCM (R403Q, R453C) and two DCM (S532P, F764L) mutant ...
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